Box of Friends

Box of Friends is an unlockable activated item added in Afterbirth.

Effect

 * Upon use, it adds one copy of each of Isaac's familiars for the duration of the current room.
 * If Isaac has no familiars, a will spawn for the duration of the current room.

Interactions

 * / : Familiars are multiplied but do not give Isaac additional lives.
 * : Two or more pills will spawn where applicable.
 * : If used before taking damage, the white fly will circle around Isaac. However, multiple white flies cannot be spawned, so using Box of Friends after taking damage or using it multiple times in a room has no effect.
 * : Adds an additional brain. When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.
 * : Will spawn a level 1 Bumbo regardless of the original Bumbo's current level.
 * : Adds two copies of each familiar.
 * / : Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
 * : Familiar will be copied.
 * Pickup generating familiars: The copied familiars will drop pickups independently.
 * : Duplicates the Head circling around Isaac's body. Only one head will shoot tears.
 * : Creates additional Incubus familiars, which share the same tear modifiers as the player.
 * / /  / : These familiars are not copied.
 * In the case of, the familiar itself doesn't appear, but instead it decreases tear delay by 2 (effective tears up) when used, without needing to take damage.
 * / : Key pieces are multiplied, but do not complete the other half.
 * : Each copy of Multidimensional Baby follows the previous copy with a 2.5 second delay.
 * : Very useful on Greed mode, as each usage will add an attacking fly, killing enemies and bosses very quickly.

Trivia

 * The Box of Friends seems to resemble the Lament Configuration of the Lemarchand's box from Clive Barker's Hellraiser.
 * Might be a very obscure reference to a Yu-Gi-Oh! card with the same name.
 * This item used to have a recharge time of 2, until an update on November 4th, 2015.
 * When playing in Korean, this item still has a recharge time of 2.

Seeds
WL8W DS4S (First Golden Treasure Room)

Box of Friends